PMN Migration 2
(Immune surveillance/anti-allergic effects)
(Immune surveillance/anti-allergic effects)
This testing involves evaluation of whether a natural product has a differential effect on migration of the polymorphonuclear (PMN) cell. The testing includes assessment of effect on random migration as well as chemotactic migration towards three chemo-attractants involved in allergic responses.
The PMN cell is a highly active and migratory cell type. The migratory behavior of this cell type is divided into at least two types:
- random migration and
- directed migration.
In this assay, the directed migration is tested towards three distinctly different chemotactic compounds involved in allergic responses:
- Histamine;
- Prostaglandin D2;
- the Epithelial Neutrophil Activating factor 78 (ENA-78).